A to Z of MS
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A to Z of MS Amantadine (Symmetrel)
Product names
Symmetrel, Lysovir
Amantadine is a drug used in the treatment of fatigue in multiple sclerosis. Studies have shown that amantadine reduced fatigue in 20-40% of people with mild to moderate MS.
How amantadine works
Amantadine is an antiviral drug, used to treat influenza infections. It is sometimes effective in relieving fatigue in MS though the mechanism for this remains unknown.
How is amantadine given?
Amantadine is taken orally as tablets.
Side effects and contraindications
Amantadine is generally well tolerated with mild side effects, which can include constipation, nausea, anxiety and hyperactivity. It is suggested that the dose is taken no later than 2pm to avoid the potential problem of insomnia or vivid dreams from the drug being taken too close to the individual's normal bedtime.
Reference
Krupp LB, et al.
Fatigue therapy in multiple sclerosis: results of a double-blind, randomized, parallel trial of amantadine, pemoline, and placebo.
Neurology 1995;45(11):1956-1961.
abstract
Pucci E, et al.
Amantadine for fatigue in multiple sclerosis.
Cochrane Database Of Systematic Reviews 2007;(1):CD002818.
abstract