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A to Z of MS Amitriptyline (Triptafen)

Product names

Triptafen

Amitriptyline is an antidepressant. In multiple sclerosis, a low dose of amitryptiline is often used for pain relief, particularly for neuropathic pain in the arms and legs, eg burning sensations, pins and needles or stabbing pains.

How amitriptyline works

Amitriptyline belongs to the tricyclic class of antidepressants. It works by altering the way in which the central nervous system reacts to pain.

How amitryptiline is given

Amitriptyline is taken orally as tablets. It is often taken at night as it can cause drowsiness. Amitriptyline normally takes between two to four weeks to take effect.

When stopping medication, speak to your doctor about gradually reducing the amount you are taking in order to avoid the possibility of withdrawal symptoms such as headache, nausea, and an overall feeling of discomfort./p>

Side effects and contra indications

Amitriptyline adds to the effects of alcohol and some other types of drug (eg, antihistamines, sedatives, tranquillisers, prescription pain medications, seizure medications, muscle relaxants, sleeping medications), possibly causing drowsiness. Be sure that your doctor knows if you are taking these or other medications.

Side effects of amitriptyline can include dry mouth, skin sensitivity, blurred vision, urinary retention and constipation. Not everyone taking the drug will experience side effects. If you do experience side effects and find they do not ease off over time, talk to your doctor. Pregnant and breastfeeding women should seek advice from a doctor.

As some of the side effects of amitriptyline are similar to common symptoms of MS, consult your doctor if an abrupt change of this type occurs.