A to Z of MS
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A to Z of MS Methotrexate (Maxtrex)
Product names
Maxtrex. Non branded versions are available.
Methotrexate is an immunosuppressant drug used in the treatment of cancer, arthritis and psoriasis.
Research in relapsing forms of multiple sclerosis has shown methotrexate to have an effect on reducing the relapse rate and in slowing progression in the short-term. Researchers in France have explored methotrexate a part of a combination therapy to control aggressively relapsing MS before moving people onto one of the other disease modifying drugs.
Studies have tested low dose methotrexate as a treatment for progressive forms of MS and found that it may have a role in slowing progression and helping with psychological symptoms in people with moderate disability.
How is methotrexate given?
Methotrexate is taken orally as tablets.
Side effects and contraindications
Methotrexate was well tolerated at the low doses used in the research. Longer-term use may be associated with serious side effects, including lung and liver problems, and the suppression of bone marrow. As a result, methotrexate is not a first line treatment for multiple sclerosis.
References
Martinelli Boneschi F, et al.
Mitoxantrone for multiple sclerosis.
Cochrane Database of Systematic Reviews 2005;(4):CD002127.
abstract
Le Page E, et al.
Mitoxantrone as induction treatment in aggressive relapsing remitting multiple sclerosis: treatment response factors in a 5 year follow-up observational study of 100 consecutive patients.
Journal of Neurology, Neurosurgery and Psychiatry 2008;79(1):52-56.
abstract
Goodkin DE, et al.
Low dose (7.5mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis.
Annals of Neurology 1995;37:30-40.
abstract
Patient Information Leaflets
- Maxtrex (EMC website)
- Find out more
- Drugs used in the treatment of MS