A to Z of MS
Click on the relevant link for more information on a topic.
A to Z of MS Tadalafil (Cialis)
Product name
Cialis
Tadalafil is a prescription medicine for the treatment of erectile dysfunction in men.
How tadalafil works
Erectile dysfuntion is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. In multiple sclerosis this is commonly associated with bladder problems and both disorders are believed to be as a direct result of damage to the nerves in the spinal cord.
Tadalafil works by delaying the action of enzymes called PDE5 (phosphodiesterase type 5), which regulate blood flow in the penis. Altering levels of this enzyme means that normal sexual stimulation leads to better erections.
How tadalafil is given
Tadalafil is taken orally at least 30 minutes before sexual activity is planned. The effect may persist for up to 36 hours. Dose ranges from 5-20mg as necessary. Maximum dose frequency is once a day, but daily use of tadalafil is not recommended.
Side effects and contraindications
Common side effects include headaches, flushing, upset stomach, visual disorders, nasal congestion and dizziness. Tadalafil should not be taken by people receiving treatment with drugs containing nitrates, such as are used to treat angina. Tadalafil must be used with caution by people with existing heart conditions or problems with liver or kidney function or low blood pressure.
Reference
Lombardi G, et al.
Efficacy and safety of tadalafil for erectile dysfunction in patients with multiple sclerosis.
Journal of Sexual Medicine 2010;7(6):2192-2200
abstract
Patient Information Leaflets
- Cialis (EMC website)